CytoGenix, Inc. (CytoGenix) is a biopharmaceutical company whose primary focus is the development and commercialization of its technologies for identifying and silencing disease causing genes, expressing proteins for applications, such as vaccines and isolating nucleic acid-based anti-microbial compounds. The Company’s three technologies comprise: gene silencing techniques single-stranded deoxyribonucleic acid (ssDNA) applicable to genes from pathogenic organisms or selected genes from a patient to prevent the expression of harmful proteins, thereby preventing or ameliorating disease; a cell free process to produce large quantities of DNA (synDNA) for use in its own products and for sale to other biopharmaceutical or life science companies, and a methodology to isolate and characterize DNA-based drugs (Oligogenix), to which harmful bacteria have not developed immunity. (Source: 10-K)
GATC Biotech (www.gatc-biotech.com), with headquarters in Constance, Germany, is a leading provider of molecular biological services and innovative bioinformatics solutions for industry and academia worldwide. GATC's portfolio contains services in the areas of genomics, transcriptomics and functional analysis, complemented by a wide range of bioinformatic software, e.g. Lasergene (DNA sequence analysis software) by DNASTAR Inc., ERGO (Genome Analysis Suite) by Integrated Genomics, as well as Mutation Surveyor/Mutation Explorer (DNA variant analysis software) and GeneMarker (Software for AFLP and genotyping) by SoftGenetics. Today, GATC has 40 employees and serves 3000 customers in 40 countries. This year GATC celebrates its 15th anniversary. Most of GATC's employees are scientists with long-term experience in biotechnology, molecular biology and chemistry. The company is ISO-certified since 1997.
OpGen offers its whole genome mapping technology on a fee-for-service, or collaborative basis. Send your DNA samples to OpGen (see Submitting Samples, below) for analysis. You will receive the whole-genome map(s), relevant analyses performed using OpGen's proprietary informatics tools, and software to utilize the map data in your genomics program.
http://www.genesisgenomics.com
Genesis Genomics is a world leader in the development of biomarkers and the marketing of products and services based on the Company's unique, proprietary, market disruptive, mitochondrial technology. Genesis Genomics has developed technologies, assays and services already on the market that will result in life changing applications for physicians and patients.
Aptagen, LLC is a biotechnology company with a rapid fast-track approach to drug discovery, drug targeting, and pre-clinical development (video/animation). Our platform technology (patent pending) is a short-cut approach to develop promising drug candidates that are deliverable to a variety of disease targets. Aptagen was formed in 2004. Operations began in 2006. The laboratory facility occupies 1,000 square feet, and contains standard equipment for molecular biological studies. Aptagen is located in Jacobus, PA, a suburb of York, beautifully surrounded by Lake Redman and conveniently situated off of route 83. The facility is a forty minute drive from Johns Hopkins University and Hershey Medical Center.
Founded in 1995, DNA LandMarks is a genomics company dedicated to delivering DNA marker services to the agricultural industry. We offer a complete range of services including: , DNA sequencing , Marker development and validation , Genetic mapping , Marker-assisted selection , Marker-assisted backcrossing , Genetic fingerprinting , Southern blots , Molecular characterization of transgenic events Our mission is to deliver valuable services that impact every stage of the agricultural value chain. Our goal is to achieve this by providing excellent service and extensive scientific background all at a competitive cost to our clients. Our site aims to introduce you to our technologies and services. If you have questions at any point, please do not hesitate to contact us. Note: Our site includes an "Instant Glossary" web tool. Anytime you see a book icon next to a word, you can pass your mouse cursor over the word and a definition will automatically appear.
http://www.dna-bioscience.co.uk
We provide expert advice and support in all aspects of DNA testing, including paternity/maternity/sibling testing, ethnicity and diagnostic testing, DNA storage and profiling and forensic defence consultancy. In addition, we also provide a range of advanced tests used by the legal services and our corporate clients, which include hair drug testing, alcohol and solvent abuse testing. The company has a large legal services client base and provides a comprehensive range of services which includes arrangement of sample collection, chain of custody quality assurance, and assistance in the interpretation of results, backed by a dedicated customer support team and overseen by the company's full time geneticist. The company recently launched a DNA testing Continuous Professional Development training programme for the legal services market which has been endorsed by the Law society. DNA Bioscience is the service partner of choice for family and immigration law firms, general practitioners, local authorities, corporate clients and consumers.
About PowderMed PowderMed (http://www.powdermed.com/) is a private immunotherapeutic company based in Oxford, UK. The Company is focused on the clinical development and manufacture of therapeutic and prophylactic DNA-based vaccines for viral diseases and cancer. The company has 4 clinical and 3 pre-clinical stage projects. The lead clinical programme has shown positive Phase I results in the treatment and prevention of human influenza. This technology is uniquely and easily adaptable to treat avian flu and to address the pandemic threat. PowderMed also has a product for the treatment of genital herpes in Phase I trials, and two partnered Phase I programmes in Cancer (Ludwig Institute) and HIV/AIDS (Glaxo SmithKline). PowderMed vaccines are delivered using PMEDTM (Particle mediated epidermal delivery), a needle-free, virtually painless delivery system that requires minimal medical training, allows self-administration and requires no refrigeration for stockpiling. Specifically, PowderMed's technology delivers DNA to the epidermal layer of the skin where it is presented to the cells of the immune network, thereby creating immunity and thus facilitating both treatment and prevention of disease. The Company has a highly experienced management team that has a combined 160 years of experience, with Rolf Stahel as the chair of the board.
GeneThera, Inc. is a development-stage biotechnology company that develops molecular assays and is in the process of developing therapeutic vaccines for the detection and prevention of food contaminating pathogens, veterinary diseases, and diseases affecting human health. The Company has developed diagnostic assays for use in the agricultural and veterinary markets. Specific assays for Chronic Wasting Disease (CWD) (among elk and deer) and Mad Cow Disease (among cattle) have been developed and are available on a limited basis. E. coli (predominantly cattle) and Johne’s disease (predominantly cattle and bison) diagnostics are in development. The Company is also working on vaccine solutions to meet the demands of veterinary industry and agriculture and healthcare industries. (Source: 10-K)
Bacterial Bar Codes, Inc., under contract with the Texas Veterinary Medical Diagnostic Laboratories, is developing a database of DNA fingerprints of bacteria that infect livestock and companion animals. The database is scheduled for completion by the end of 2002.
Genizon BioSciences Inc., founded in 1999, is the only source for GeneMaps - omprehensive maps of genes, genetic markers, biochemical pathways and drug targets that are unequivocally involved in causing human disease-accelerating the development of safer, more effective, personalized medicines. Genizon's proprietary, automated gene discovery platform using genome-wide association studies involving thousands of members of the Quebec Founder Population provides unprecedented understanding of the genetic origins and mechanisms of common diseases, resulting in the best possible drug targets and genetic markers. Genizon is conducting gene discovery programs in more than 25 common diseases. Genizon also provides high throughput, high quality SNP genotyping, genetic analysis, gene expression and pharmacogenomics services to academic institutions, research organizations and the biopharmaceutical industry.
Exiqon A/S is a Denmark-based company active in the pharmaceutical industry. It is a provider of gene expression analysis products for the life sciences. The Company’s product portfolio includes the miRCURY LNA product line for microRNA research. It has also developed its proprietary Locked Nucleic Acids (LNA) and Anthraquinone (AQ) technologies. Exiqon has entered into partnerships with Roche Diagnostics, Invitrogen, Fischer Scientific International Inc. and Luminex Corporation. The Company has distributors in Australia, China, Hong Kong, India, Italy, Japan, South Korea, New Zealand, Singapore and Spain. Exiqon A/S is operational through Exiqon, Inc in the United States. On February 29, 2008, the Company acquired Oncotech that develops and markets diagnostic tests designed to optimize the treatment selection for cancer patients.
Pyrosequencing AB develops, manufactures and sells complete solutions for rapid applied genetic analysis based on its proprietary Pyrosequencing technology, a simple-to-use DNA sequencing technique. Pyrosequencing leads the global market in Applied Genomics with over 150 systems sold to major pharmaceutical and biotech companies and prestigious research institutions worldwide. Pyrosequencing is broadly applicable for the analysis of single nucleotide polymorphisms (SNPs) and for the identification and quantification of short DNA sequences used in bacterial and viral typing. The Company's Molecular Diagnostics Business is establishing collaborations with industry leaders to identify new product opportunities in disease diagnosis, clinical prognosis and pharmacogenomics. The Company's products include the bench-top PSQ96 System and a high-throughput PTP system which utilize proprietary software and reagent kits. Among Pyrosequencing's customers are AstraZeneca, GlaxoSmithKline, Merck, the NIH, the Harvard Center for Cancer Prevention, the Karolinska Institute, Biogen, Oxagen, Ltd., and DuPont Agriculture.
ZYCOS Inc. is a privately held drug development company focused on developing antiviral and oncology products. Since its inception in 1996, the Company has generated a series of distinct new medical entities (NMEs) and with these conducted multiple clinical trials in chronic viral diseases and cancer. By exploiting an integrated suite of proprietary drug formulation technologies, the Company has consistently demonstrated the ability to accelerate product development, via formulation optimization with resulting clinical success. In partnering its lead drugs to experienced pharmaceutical companies, ZYCOS believes it can maximize it's value through efficient launch, marketing and distribution of its' products. In order to capture a larger fraction of the value it has created, ZYCOS will retain commercialization rights to drugs developed for specific indications in which large marketing efforts are not critical.
Lorantis is pursuing immunology drug discovery and development through a unique molecular mechanism, Notch, that can be targeted to enhance or suppress antigen-specific immune responses. The company has two broad platforms to generate multiple products in areas of high unmet medical need. Antigen-specific immune suppressors are being developed for the treatment of allergy, asthma, autoimmune diseases and transplant rejection. By enhancing the immune response, Lorantis is addressing cancer and infectious diseases. The company has received venture backing from Apax Partners, Abingworth Management, Schroder Ventures Life Sciences, JP Morgan Partners, Quester, The Wellcome Trust and Northern Venture Managers.
Integrated DNA Technologies sells short strands of DNA called oligonucleotides (from the Greek root of "oligo" meaning "few"). In order to better understand how these are useful, you'll have to know a bit about DNA itself. DNA is "the blueprint for life" and encodes instructions for all of life's processes. DNA is a complex long thin molecule (strand) that is made from 4 possible building blocks called "bases". These bases are called Adenine, Cytosine, Guanine and Thymine, and the precise order of these bases is a code for information. In living organisms, DNA strands can be millions of bases long and therefore contain huge amounts of information. This complexity is responsible for the vast complexity and diversity of life on earth. The way that one strand of DNA specifically binds a second strand of DNA allows scientists to use short DNA strands (oligos) as research tools. A short synthetic piece of DNA (usually around 20 bases long) can be used to bind or find its matching sequence even in a complex mixture of millions of unrelated pieces of DNA. It is this unique fact that allows researchers to decode and study the genetic makeup of any living organism. Using new oligo-based technologies, a revolution is underway where we are beginning to catalog the complete genetic makeup of hundreds of living things, ranging from bacteria to humans. The human genome alone contains over 3 billion bases of DNA, so projects of this kind tend to be very complex and often take years to complete. Scientists often start the research knowing the DNA sequence for the organism that they are interested in studying. Given a known DNA sequence, they can easily design a short oligo that can be used to perform a variety of tasks. It is this short single-stranded DNA that the researcher orders from IDT. Living systems don't discriminate DNA that is synthesized chemically from DNA taken directly from an organism, allowing researchers to use IDT's custom made oligonucleotides as if they had existed naturally. IDT manufactures the oligo using chemical DNA synthesis machines designed and built in-house. We've refined the process to the point where we can receive an order as late as 1:00pm and have the desired oligo in the researcher's hands the next morning. Our customers range from small university labs of only a few scientists to global pharmaceutical companies, and everything in between. Some common uses for oligos include: Diagnostic tests for genetic diseases, like breast cancer or cystic fibrosis. Diagnostic tests for infectious diseases, like Hepatitis or AIDS. Research to discover new drugs or treatments for a variety of diseases. Producing safer and more plentiful agricultural products. IDT is the largest manufacturer of custom oligo products in the US today. We became the industry leader in this competitive field by maintaining the highest standards of quality, service, and technical know-how. Since oligos are used in almost all areas of medical and pharmaceutical research, we are shielded somewhat from "razor's edge" research that make or break many small or mid-size biotech companies. Our future is bright and we continue to expand even in a sluggish economy.
Founded in 1994 and based in Beltsville, Maryland, MetaMorphix®, Inc. is a privately held life sciences company that uses the code of life, DNA, to improve the global food supply and human health. In livestock, we help our customers produce higher quality, nutritious meat more efficiently; and in healthcare, we discover and license targets to pharmaceutical companies that develop therapies for better management of metabolic and muscular degenerative diseases. The company is developing a pipeline of innovative products addressing all major livestock sectors including cattle, swine, poultry and aquaculture, as well as developing products that enhance the health of companion animals.
GeneLink, Inc.( GeneLink) is a bioscience company and was originally organized to offer to the public the safe collection and preservation of a family's deoxyribonucleic acid (DNA) material for later use by the family to identify and potentially prevent inherited diseases. The Company has created a methodology for single nucleotide polymorphism (SNP)-based genetic profiling and focuses to market and/or out-license these assessments to companies that manufacture or market to the nutraceutical, personal care, skin care and weight-loss industries. The Company has developed SNP-based genetic profiles (named GeneLink Nutragenetic Profile and Dermagenetics profiles). These profiles provide a means of predicting an individual's inherent genetic capacity to combat such conditions as oxidative stress and other important selected areas of physiologic health. (Source: 10KSB)
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